Mark J Thomas

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Neurobiology of drug-induced plasticity and addiction, behavioral neuroscience, transgenic mice, cellular electrophysiology.

Educational Background & Specialties

Educational Background

  • Ph.D.: University of California, Los Angeles, California, 1998.


  • psychology
  • neurobiology of drug-induced plasticity and addiction
  • behavioral neurogenetics
  • transgenic mice
  • cellular electrophysiology
  • Rothwell P.E., Thomas M.J. and Gewirtz J.C. (2011). Protracted manifestations of acute dependence after a single morphine exposure. Psychopharmacology (Berl),
  • Rothwell P.E., Kourrich S. and Thomas M.J. (2011). Synaptic adaptations in the nucleus accumbens caused by experiences linked to relapse. Biological Psychiatry, 69(11), 1124-26. Link
  • Rothwell P.E., Kourrich S. and Thomas M.J. Environmental novelty causes stress-like adaptations at nucleus accumbens synapses: implications for studying addiction-related plasticity. Neuropharmacology, 61(7), 1152-59.
  • Rothwell P.E., Gewirtz J.C. and Thomas M.J. (2010). Episodic withdrawal promotes psychomotor sensitization to morphine. Neuropsychopharmacology, 35(13), 2579-89. Link
  • Xie K., Allen K.L., Kourrich S., Col√≥n-Saez J., Thomas M.J., Wickman K. and Martemyanov K.A. (2010). Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat Neurosci., 13(6), 661-63. Link
  • Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M.J., Wickman K., Giesler G.J. Jr and Martemyanov K.A. (2010). R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharmacology, 35(4), 1040-50. Link
  • Petzold A.M., Balciunas D., Sivasubbu S., Clark K.J., Bedell V.M., Westcot S.E., Myers S.R., Moulder G.L., Thomas M.J. and Ekker S.C. (2009). Nicotine response genetics in the zebrafish. Proc. Natl. Acad. Sci. USA, 106(44), 18662-67. Link
  • Kourrich S. and Thomas M.J. (2009). Similar neurons, opposite adaptations: psychostimulant experience differentially alters firing properties in accumbens core versus shell. Journal of Neuroscience, 29(39), 12275-83. Link
  • Rothwell, P.E., Thomas, M.J. and Gewirtz, J.C. (2009). Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure. Neuropsychopharmacology, 34(10), 2285-95. Link
  • Kourrich, S., Rothwell, P.E., Klug, J.R. and Thomas, M.J. (2007). Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. Journal of Neuroscience, 27(30), 7921-28. Link
  • Sun M., Thomas M.J., Herder R., Bofenkamp M.L., Selleck S.B. and O'Connor M.B. (2007). Presynaptic contributions of chordin to hippocampal plasticity and spatial learning. Journal of Neuroscience, 27(29), 7740-50. Link
  • Ferguson S.M., Thomas M.J. and Robinson T.E. Morphine-induced c- fos mRNA expression in striatofugal circuits: modulation by dose, environmental context and drug history. Neuropsychopharmacology, 29, 1664-74. Link
  • Dong Y., Saal D., Thomas M.J., Faust R., Bonci A., Robinson T.E. and Malenka R.C. (2004). Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice. Proc. Natl. Acad. Sci. USA, 101(39), 14282-87. Link
  • Thomas M.J. and Malenka R.C (2003). Synaptic plasticity in the mesolimbic dopamine system. Philos. Trans. R. Soc. Lond. B Biol. Sci., 358(1432), 815-19. Link
  • Thomas M.J., Beurrier C., Bonci A. and Malenka R.C. (2001). Long-term depression in the nucleus accumbens: A neural correlate of behavioral sensitization to cocaine. Nat. Neurosci., 4(12), 1217-23. Link
  • Thomas M.J., Malenka R.C. and Bonci, A. (2000). Modulation of long-term depression by dopamine in the mesolimbic system. Journal of Neuroscience, 20, 5581-86. Link
  • Achievement Rewards for College Scientists Fellowship, 1992 - 1993
  • NIH Traning Grant recipient, 1996 - 1998
  • Individual NIDA NRSA Posdoctoral Award, 1999