Prof Bonnie Klimes-Dougan

Photo of Prof Bonnie Klimes-Dougan

Contact Me

klimes@umn.edu
612-626-4347

Dept of Psychology
N412 Elliott Hall

75 E River Rd

My long-term goal is to explicate risk factors associated with early stages of depression and suicidal risk in an effort to more effectively intervene. By adolescence, approximately 10 to 15% of the population will experience a clinical depression. Early onset depression tends to be accompanied by a more severe course of subsequent illness and is associated with considerable morbidity (e.g., suicidal behavior). Efforts to target children at risk for depression, prior to or early on in the disease process are thought to be favorable approaches to facilitating adaptation and minimizing risk. To this end, my work has utilized developmental and neuroscience approaches that examine the stress/emotion regulatory systems implicated in depression. Recent work has focused on systems known to be critical to emotion/stress regulation including the assessment of key front-limbic neurocircuitry (e.g., using imaging techniques) and associated physiological (e.g., HPA axis) systems. A second theme of my research pertains to identifying factors that potentially modify these risk trajectories and have the potential to influence neurobiological regulatory processes that are disrupted in depressed youth (e.g., parenting emotion socialization practices, psychosocial prevention efforts).

Educational Background & Specialties

Educational Background

  • Ph.D.: Psychology, Flordia State University, 1992.

Curriculum Vitae

Publications
  • Westlund Schreiner, M.*, Klimes-Dougan, B., Parenteau, A.**, Hill, D.**, & Cullen, K.R. (accepted). A framework for identifying neurobiologically-based intervention targets for NSSI. Current Behavioral Neuroscience Reports.
  • Cullen, K.R., Padilla, L.E.*, Papke, V.N.**, & Klimes-Dougan, B. (accepted). New somatic treatments for children and adolescent depression, Current Treatment Options in Psychiatry.
  • Klimes-Dougan, B., Chong, L.S.**, Samikoglu, A.*, Thai, M.*, Amatya, P.*, Cullen, K.R., & Lim, K.O. (accepted for publication). Transcendental meditation and hypothalamic-pituitary-adrenal axis functioning: A pilot, randomized controlled trial with young adults. Stress.
  • Cullen, K.R., Westlund Schreiner, M.* & Klimes-Dougan, B. (in press). Commentary: The Neural Basis of Social Evaluation in Adolescents with Non-Suicidal Self-injury. EClinical Medicine.
  • Westlund Schreiner, M*., Mueller, B.A., Klimes-Dougan, B., Begnel, E.D.*, Fiecas, M., Hill, D.**, Lim, K.O., Cullen, K.R. (in press). White matter microstructure in adolescents with non-suicidal self- injury. Frontiers in Psychiatry, Section Child and Adolescent Psychiatry.
  • Westlund Schreiner, M.*, Klimes-Dougan, B., Mueller, B.A., Nelson, K., Lim, K.O., Cullen, K.R. (accepted for publication). Neurocircuitry associated with symptom dimensions at baseline and with change in borderline personality disorder. Psychiatry Research: Neuroimaging.
  • Klimes-Dougan, B., Begnel, E.*, Almy, B.*, Thai, M.*, Schreiner, M.W.*, & Cullen, K. (2019). Hypothalamic-pituitary-adrenal axis dysregulation in depressed adolescents with non-suicidal self-injury. Psychoneuroendocrinology, 102, 216-224.
  • Westlund Schreiner, M.*, Klimes-Dougan, B., & Cullen, K.R. (2019). Resting state functional connectivity of the precuneus associated with suicidality in adolescents with major depressive disorder. Suicide and Life Threatening Behavior, 49, 899-913.
  • Gunlicks-Stoessel, M., Mufson, L., Berstein, G., Westervelt, A., Reigstad, K., Klimes-Dougan, B., Cullen, K., Murray, A., Vock, D. (2019). Critical decision points for augmenting interpersonal psychotherapy for depressed adolescents: A pilot SMART. Journal of the American Academy of Child and Adolescent Psychiatry, 58, 80-91.
  • Haynos, A.F., Camchong, J., Hall, L.M.J., Lavender, J.M., Peterson, C.B., Crow, S.J., Klimes-Dougan, B., Cullen, K.R., & Lim, K.O. (2019). Resting-state functional connectivity of reward and habit networks and associations with symptom expression in anorexia nervosa. Human Brain Mapping, 40, 652-662.
  • Cullen, K.R., Amatya, P., Albott, S., Carstedt, P., Westlund Schreiner, M.*, Ren, Y., Horek, N., Roback, M., Eberly, L.E., Lim, K.O., & Klimes-Dougan, B.s (2018). Intravenous Ketamine for adolescents with treatment-resistant depression: Preliminary results from an open label study. Journal of Child and Adolescent Psychopharmacology, 28, 437-444.
  • Koenig, J., Westlund Schreiner, M.*, Klimes-Dougan, B., Ubani, B., Mueller, B., Kaess, M., & Cullen, K.R. (2018). Brain structural thickness and resting state autonomic function in adolescents with major depression. Social Cognitive and Affective Neuroscience, 13, 741-753.
  • Klimes-Dougan, B., Westlund Schreiner, M.*, Thai, M.*, Reigstad, K., Gunlicks-Stoessel, M., & Cullen, K.R. (2018). Neural and Neuroendocrine predictors of pharmacological treatment response in adolescents with depression. Progress in Neuropsychophmacology & Biological Psychiatry, 81,194-202.
  • Koenig, J., Westlund Schreiner, M.*, Klimes-Dougan, B., Ubani, B., Lim, K.O., Mueller, B., Kaess, M., & Cullen, K.R. (2018). Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression – Preliminary findings from a pilot study. Psychiatry Research: Neuroimaging, 281, 35-42.
  • Klimes-Dougan, B., Klingbeil, D.K.,* Houri, A.,** Cullen, K., Gunlicks-Stoessel, M., & August, G. (2018). A pilot study of stress system activation in a targeted prevention program: Implications for personalization. International Journal of Molecular Sciences, 19(2), 36.